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Episodes

Don't kink-shame the promiscuous CBD. It's okay that in a world of orthosteric normative binding, CBD is into allosteric binding. In fact, CBD is not just into any allosteric binding. CBD is into negative allosteric binding. If none of that makes any sense to you, don't worry. We are going to take a deep dive into how the famous cannabinoid, CBD, interacts with the cannabinoid receptor CB1. And it doesn't bind like a key into a lock, which is how pharmacy school told Trevor that all ligands bind to their receptors. Like all things cannabis, things are weirder, more complicated and more nuanced than our co-host, Trevor, thought. Put your science toques on and let's skate into some CB1 receptor research.

Kirk and Trevor meet Sean Boyd, a member of the Shinnecock Indian Nation and discuss the operations of Little Beach Harvest, a cannabis dispensary owned and operated by the Shinnecock tribe. The key to this episode is the community leverages its sovereign status to create its own cannabis regulations, allowing for indoor cultivation and a more customer-centric approach. The community has created a welcoming, community-oriented experience and supports Shinnecock entrepreneurs and businesses. The episode touches upon the history of economic development challenges and the ongoing fight for sovereignty. Little Beach Harvest is in a unique position as a tribally-owned cannabis business operating on sovereign land.

The conversation with BioSource Botanicals continues. In Part 2 Kirk and Trevor look deeper into the use of cannabis and cannabis-derived products offered by BioSource Botanicals. The expert panel discuss the differences in absorption and bioavailability between topical, sublingual, and edible cannabis products. They emphasize the importance of using whole plant extracts rather than isolated compounds, as well as the potential benefits of targeting mitochondrial health. The discussion also touches on the challenges of regulating the cannabis industry and the need for more scientific research to ensure quality and consistency in cannabis products.

This episode of Reefer Medness - The Podcast features a discussion with a team of experts from BioSource Botanicals, including a pharmaceutical microbiologist, a cannabis clinician, and a pre-clinical research chemist. Kirk and Trevor discuss the importance of mitochondrial health and how the endocannabinoid system plays a crucial role in maintaining it. The experts explain the benefits of using whole raw plant extracts, including the “ensemble effect” where different compounds work synergistically, and how this can be more effective than isolated cannabinoids. Kirk brings a My Cannabis Story from local budtenders and how they provide guidance to customers seeking cannabis-based wellness products.
Sunday, 26 January 2025 15:07

EV1 - Mitochondria Health with Expert Panel

This is our first full length Video episode. Kirk and Trevor talk with the research team from BioSource Botanicals, an international collaboration of independent researchers and experts who are uniting medicine with the wisdom of nature and modern science. Learn how cannabis is essential to mitochondria health and how raw cannabis creates an Ensemble, rather than an Entourage, Affect. In this episode passionate people go deep into the science of their one-of-a-kind therapeutics. https://biosourcebotanicals.com

 

 There is an app specifically designed to sell more weed. In this episode, Kirk and Trevor hear the story of a serial entrepreneur who has curated a comprehensive marketing platform empowering dispensaries and other cannabis companies to promote their products within the law. This is yet another game changing idea from Carl Sailing, the creator of “High Day” his all-in-one marketing command centre. He shares his cannabis story, business successes, and how his new project will thrust cannabis businesses into the digital spotlight. This episode is a must listen for those working within restricted industries facing regulatory challenges and regulatory misconceptions.

Here is yet another story of how individuals found cannabis to be beneficial for their own personal medical needs. The difference in this story? These people went on to grow a grassroots organization called EduCanNation, a non-profit association of Certified Cannabis Educators. While many traditional healthcare professions remain hesitant or outright dismissive of cannabis medicine, EduCanNation is stepping up to bridge the gap between scientific understanding, consumer needs, and the ever-changing legal landscape. The leaders within EduCanNation aim to set the national standards for all Cannabis Coaches and Educators. In this episode, Kirk and Trevor continue their discussion on the emergence of Cannabis Coaches and Educators—an unregulated, but increasingly necessary role—seems to be a natural response to the gaps in education and access that exist in the heavily regulated cannabis space.

Tuesday, 31 December 2024 18:12

E137 - Ethan Russo - Anxiety, Limonene & CBG

Dr. Ethan Russo has made immense contributions to the understanding of cannabis. 2024 was particularly productive as Dr. Russo’s name kept popping up in some very interesting papers. We got him to chat with us about two of them.

First there is the entourage effect paper. The entourage effect is the idea that different cannabinoids, terpenes and other components of the cannabis plant work together synergistically to give a desired effect. Professor Raphael Mechoulam and colleagues first talked about the entourage effect amongst endogenous cannabinoids in the human body. Dr. Ethan Russo and others have expanded the idea to phytocannabinoids and other cannabis plant components. But it is still just an idea. Now there is a trial that looks at if inhaled limonene makes THC cause less anxiety in people. This could be the beginning of the evidence to validate the entourage effect.

Second, we chatted about a CBG paper. We have a lovely sound bite that describes CBG as a “bubble bath for your brain”. This study gives us some early evidence of the clinical effects of CBG, and whether it actually reduces anxiety.

Let’s do some learning!

The Canadian Medical Cannabis Program has been available for more than two decades, yet the process of obtaining cannabis as medicine remains very cumbersome. In comparison, Recreational Cannabis, seen as a substance of misuse, is easy to acquire. When people express an interest in trying cannabis as a medicine to their health care team, many health practitioners simply direct their patients toward the Rec market knowing (or maybe not) the restrictions the Cannabis Act places on budtenders. Budtenders cannot discuss health conditions with customers. While many health professionals continue to ignore the highly regulated medicinal cannabis system, a group of entrepreneurs calling themselves Cannabis Coaches, are filling the need. In this episode we learn how certified Cannabis Coach Terese Bowors started a small business educating people about medicinal cannabis. We come to understand how a group of non-regulated health educators are developing their own Standards of Practice.

Tuesday, 19 November 2024 08:20

E135 – Shiva Dances within Buddha’s Garden

Regular users of cannabis will -- often self-consciously -- admit to having a spiritual relationship with the plant.  Will Johnson, a teacher of Buddhist dharma since 1972, explains how he is ‘something of an anomaly and outlier when it comes to the use of cannabis.’ In his book “Cannabis in Spiritual Practice: The Ecstasy of Shiva, The Calm of Buddha,” Will applies his understandings with living by The Buddhist’s precepts, as an adult.  He believes his positive pathways toward full Embodiment is better achieved when he weaves his dance with Shiva, while enjoying the fruits of Buddha’s Garden.  In this episode, Kirk and Trevor conclude Will may be onto something. What if everyone in the world simply took a few deep breathes, passes the chillum, and spontaneously started to dance?  What if…

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