Dr. Ethan Russo
E137 - Ethan Russo - Anxiety, Limonene & CBG
Dr. Ethan Russo has made immense contributions to the understanding of cannabis. 2024 was particularly productive as Dr. Russo’s name kept popping up in some very interesting papers. We got him to chat with us about two of them.
First there is the entourage effect paper. The entourage effect is the idea that different cannabinoids, terpenes and other components of the cannabis plant work together synergistically to give a desired effect. Professor Raphael Mechoulam and colleagues first talked about the entourage effect amongst endogenous cannabinoids in the human body. Dr. Ethan Russo and others have expanded the idea to phytocannabinoids and other cannabis plant components. But it is still just an idea. Now there is a trial that looks at if inhaled limonene makes THC cause less anxiety in people. This could be the beginning of the evidence to validate the entourage effect.
Second, we chatted about a CBG paper. We have a lovely sound bite that describes CBG as a “bubble bath for your brain”. This study gives us some early evidence of the clinical effects of CBG, and whether it actually reduces anxiety.
Let’s do some learning!
E107 - Ethan Russo - Cannabinoid Hyperemesis Syndrome and THCV
A short intro for the eminent Dr. Ethan Russo is challenging. Ethan Russo is a neurologist who explored the Amazon rain forest in the 90's to explore medicinal plants with aboriginal tribes. He returned to the USA and became interested in medicinal cannabis. He quickly became an expert in the field, and worked as a consultant for GW Pharmaceuticals. Later, as a Senior Medical Advisor for GW, he was involved with the development of Sativex and Epidiolex. Dr. Russo founded CReDO Science, creating innovative products and services related to cannabis and the endocannabinoid system. Trevor and Dr. Russo discuss Cannabinoid Hyperemesis Syndrome (CHS). It is a relatively rare, but very unpleasant condition that causes some heavy users of cannabis to be very nauseous and vomit a lot. Dr. Russo and collaborators have developed a genetic test that may be able to predict who will get CHS and thus who might want to avoid THC containing cannabis altogether. Then Trevor and Dr. Russo discuss THCV. Come hear about all the potential indications for this lesser known cannabinoid. Make sure you listen to the very, very end of this episode for a hidden my cannabis story.