Episode Transcript

Trevor:  Kirk We're back.

Kirk:  How's it going Trevor.

Really good, the second time we're talking with Yvette. And this time we actually finally get around to talking about stuffing things up your nose.

Kirk:  Yeah the Nozzr^TM. It's uh it's quite the product it's quite the product. Um as i as i said in the uh Cream of the Crop uh edition this is a lady that I contacted to talk specifically about this product that she sent me unsolicited. She sent this product and um and we got into a longer discussion and that was the other episode that you should go back and and meet her again but this is um This is her product called the Nozzr^TM and I love the history. Again, I did not know the person I was talking to. It was a cold call. We started talking. I discovered she's a respiratory therapist. She's a lady that has MS and she uses cannabis therapeutically for her MS. And she calls herself a unicorn because her MS is different. You are a man that's very in tune to MS.

Trevor: We'll say I've got an interest in. I'm not an expert by any stretch, but there's lots of people in our area with MS. So I just talk to people in my day-to-day with MS and for a bunch of years I was involved with the MS Society, so got to meet a whole bunch of other people with MS So yeah, we'll call it a special interest of mine, but it's not like I'm an MS pharmacist or anything.

Kirk:  No, but you understand MS, you understand the process, and you've got a clinical understanding of MS. Sure. So, and do you know many of your MS clients are using cannabis as therapy?

Trevor: People have been talking about... Using MS no using uh cannabis for a long time uh Stativex was a commercially available actually nasal spray uh but it hasn't been it's so it wasn't pulled from the market or anything but i haven't seen it around in several years i'm going to say it sort of became I’m getting my timelines a lot but I'm gonna say 10-ish years ago it was around and seem to be both THC and CBD in the spray. If I'm remembering properly and yeah so people have been and when legalization was like commercial rec legalization was talked about people in the MS world were talking a lot about you know should they use it shouldn't they use it what should they be looking for and one of the practically non controversial statements about cannabis is cannabis being used for MS spasticity is pretty much you can't there's there's a it is like about three things that no one argues that cannabis can do and MS spasticity with cannabis seems to be one of those things that and argues that, you know, that, yeah, that's a treatment.

Kirk:  So it does actually diminish the spasticity.

Trevor: It does, yes.

Kirk:  And do we know if it's the CBD or the THC or the combination of both?

Trevor: I don't know if we know that.

Kirk:  Okay, fair enough, fair enough. And I didn't mean to test you, just that I know you have an interest in MS. Why don't we just jump into the conversation? I think you can sense that I am enjoying the conversation and it went way so long. And again, hear Clive in the background, her husband was obviously there helping her because she talks about getting a brain fog every so often and he was throwing sort of like tidbits out as she was talking to me. So listen for Clive as well. All right, let's listen to Yvette.

Yvette Webb: So it all started with COVID.

Kirk:  Everything started with COVID.

Yvette Webb: I know. And, and, and also I was around during the first SARS. I wasn't working, uh, clinically, but I was working in the industry in the medical industry. And so I still had a lot of colleagues working. So we knew a lot about the whole respiratory and, and, um, so when, when COVID first came out, everyone was trying to figure out what to do and they were doing mouth washes and rinses and stuff for the throat and this virus hangs out above your oral airway in the nasal pharynx and that's where it accumulates and so there were two studies and again it goes back to terpenes there were 2 studies that were done by the same author Yang et al 2012 and 2011 on terpenes and coronaviruses. With my background, a lot of respiratory viruses are coronaviruses, so they have that shape, they have those spikes. Some flu viruses also have that. And so this was done in bird flu, these studies. And what was interesting, and I shared the articles with some of the Brainiac PhD people I know, because I, you know, I. It took me 10 years to do a degree in biology because I was working and stuff. And then when I finished it, people said, so are you going to go get your master's? No, I'm good. And so the papers were done really well because not only did they say, oh, these terpenes can stop the virus, they actually showed you how it did it. And it didn't care what the spike was or what mutated on the spike. It allowed the virus to go into the cell, but it, and you know, viruses, all they, all, they want to do is make copies of themselves. That's their goal. So they, so it lets the virus go into this cell, but it messes up so it can't reproduce. And that's how it decreases the virus. It kills the virus and so, because they were terpenes and you, know, my brain plant, plant base, you know. If we can decrease the viral load. Our philosophy was, well, if we could make a product similar, you know, we were doing the hand washing and masking, you know back and vaccines weren't out yet. So if we spray our nose and reduce the viral road load, then, you know we could work with that. And so the two terpenes are 1,3-cineal and pinene. Are the two. And so we made a, a, uh, dosed that that's another thing on medical we can talk about is dosing cannabis. So dose nasal spray, um, that, uh this was a child lock at the time, right? And throw in CBD cause CBD is so good with, um um, just tempering your, your immune system. If it goes crazy, it's a great anti-inflammatory. Understanding the structure of the nose and the layer of mucus and what's in the mucus are your immune cells and how you could capture that. And so we did a formula and we were using it saying you go out, you spray your nose, you come in the house, you wash your hands, you spray, your nose. That was where we were starting to work with this. And then we thought, okay, we knew that once you started having symptoms of COVID, it was in your chest, right? You started getting. So how do you translate those products to the chest? So it was about what we still want to vaporize it. And we want it to go into the lungs. But it'd be good if it could go through the nose too, because that's where everything comes in through the nose, right? And accumulates there. And so this was, you know, vape carts, this was early, early, really vape cards, like we weren't even talking about that.

Kirk:  So you put that knowledge together and you said to yourself, only as a respiratory therapist can, is I've got an accumulation of viruses in my nasopharynx. I should flush that with nasal rinse or terpene rinse or CBD rinse. So you're thinking of prevention as well, and you come up with this Nozzr^TM. And obviously, from a recreational perspective, this also has benefits. But OK, so OK, carry on from that. I just wanted to just make sure I'm on the right track.

Yvette Webb: So we figured, okay, let's try and do a vapor, a vape cart with the terpenes and maybe and some CBD and back then that's when you know all the stuff about they were putting in fillers and so I just I worked with just CBD and the terpene and some other terpene because Eucalyptol can be pretty nasty, it can be very off-putting, and even in the nasal spray. So there's other terpenes in there that tamper that so you don't even...

Kirk:  God, that would blow your eyeballs out if you breathe in eucalyptus in your nose.

Yvette Webb: And then, so again, my background in respiratory therapy, we used to have these little devices like that and they were called, they were used for neonates to clean out their nostrils.

Kirk:  Little vacuums, right?

Yvette Webb: The shape of them.

Kirk:  Yeah, yeah, yeah. I've used them. Yeah.

Yvette Webb: Yeah. So, um, and, and I used to work for that company. So one of the companies that did a lot of neonatal products. So I worked on that design idea, but went with the two prongs and worked with tilt holdings, which is C cell, which makes cartridges, vape carts and batteries. And they donated all kinds of product for us to play with. And we got... And so we figured it out, but then the vaccines came out and everything. And at that point, I wasn't even thinking about cannabis as recreational because back then you could, the vape carts out, you could smell and taste butane and you know, products weren't clean at all. But we still, we still went ahead and because of my background too, with, you know, asthma and stuff and, and there's some nice little handheld nebulizers out, especially in the European market in, in, on, in Canada, we like MDIs. We like the puffers. Other countries do not use the puffer as much as we do. And so I knew that because of, my background in industry as well and working with companies that had these handheld. So I also thought of it that way. Of getting product. You know, you think, oh, the nose is going to capture everything. But you need the right size of aerosol, and it'll go through the nose and into your lungs. And it's a lot a lot easier to do than than going through your mouth. It's more natural and breathing, but that we'll talk about noser with that. So we went ahead and further develop this. So, we found a local company to do 3d printing started there. And, um, at one point, some mucky mucks from Tilt holdings were in town and Jupiter and the local, uh, manager, Jerry, um, we sat down and met with them. And by then, some of the vape carts were getting better. They were getting more into the, um, some cleaner resin. And so we met in a, in a Second Cup and of course they all had their vapes with them.

Kirk:  Yeah, everybody has their vapes.

Yvette Webb: Yeah. So we, so one of the attendees, um, took out a vape cart and we gave them each a noser and they passed around the vape card with their own noser and they they were experiencing different flavors and tastes. And this one woman swore she could taste juicy fruit gum. In that vapor. And so, and we know that 80% of taste is through your nose. Yeah. You know, you have a cold, nothing tastes right. And so it was quite interesting at that point. And we're like, okay, so maybe we are onto something here.

Kirk:  Oh yeah, you are actually.

Yvette Webb: And so we, you know, we're a party of two and so things even from designing not only the product and figuring out how to do this and not speak Mandarin.

Kirk: Sure.

Yvette Webb: And and the packaging you know we want something disposable, but we want something we can use a picture because we're not cannabis right right uh we got to have English or French we have to put the warnings on because we don't want try it on nicotine i dare Thank you.

Kirk:  No, I don't do nicotine, but...

Yvette Webb: But I double-dog dare anyone with a nicotine vape to try that and they will never do it again It's just yeah, it's yeah But and then we also had to put a warning on there and people have to understand this about choking hazards small parts not for children under three years or Any individuals who have a tendency to place in edible objects in their mouths?

Kirk:  Well, it's like.

Yvette Webb: In English or French.

Kirk:  Yeah, but it's like ladders. You have to tell people this ladder is unsafe. Yeah. So how long has it been on the market?

Yvette Webb: So it's been on, you know, we thought in our and we've been so naive and industries different and we were out of commission for five years between the MS and the the myeloma. But I mean, people were like, people who who saw it think it's weird. Some people find it triggering if they've ever had a cocaine addiction.

Kirk: Interesting.

Yvette Webb: But but people who our vapors, we're finding out that, um, you know, and you read about these, some people will go through a gram cartridge in a week. Yeah. And so why is that part of it is too, is trying to get to that love that, you know? And I've done it when I, when I wasn't consuming the right cannabis, you're trying to to that point

Clive: chasing

Yvette Webb: And you're chasing, right? And that's when I went the only time I really greened out, but not understanding things. But what we've noticed is because you're now going through the nose and your, um, olfactory organ, your, your smell organ has endocannabinoid receptors. And so they can transmit right into your amygdala. Which is about memory and stuff. And that's part of smell too, but also it can quickly go into the areas where you have the CB1  and CB2 receptors. So I think part of it is, and this is just my theory is when you inhale orally and you go through the, your lungs, then you go to your blood, then you have to distribute it throughout your body. And for certain things you really want to go to those receptors in your brain, especially chronic pain, anxiety, And so if you go through your nose, you're able to reach those quicker and in body sense, milliseconds may make it. I don't know. I don't have enough about this. It's just questioning, but we've seen it. And what's happening is people are requiring less. There's an issue with tolerance. If people are hauling on a vape cart orally, they can help with their tolerance if they start a different route.

Kirk:  Yeah, no, when I told Trevor that I had received these two Nozzr^TM, we both had a good giggle over it.

Yvette Webb: Oh yeah, I know.

Kirk:  Yeah, we had a good giggle. But I started to question about the whole pharmacology of it, the pharma, you know, and I've done scans and I'll do a little bit more reading when I talk to Trevor. But I'm looking forward to Trevor to talk about this because I see this as both medicinal and recreational benefits. Medicinally, of course, like you said, When I tried this, it was almost immediate. The first thing that popped were the terpenes. It was like, and I think I said to you that I grow my own and I've been consuming my own usually through smoke. And as much as I like vaping, I find vaping sometimes just a little too difficult. It's easier just to take a reefer with me for a walk or a one hit and go for a walk. I like my flower, right? But I tried this, I tried and it was immediate. It was like, oh, I haven't smelled those terpenes in my grow, in my AK-47 grow. That's astounding. And then I realized, oh hold on.

Yvette Webb: This is it? I know!

Kirk:  It's hit faster and those were two real life applications and I went there's something here this is because again as a nurse I can't get gifts. But I will say that this was unsolicited, and I guess you can confirm that. Thank you for sending this. But I, I will recommend nasal inhalation as medicine and also for flowers. I mean, I don't recommend vapes. Like I think, again, I told you, I don't use vape cards. I don get them. And the people that I know that use them ironically talk about their anxieties and it's like, well, get away from the vape card. Sorry.

Yvette Webb: Well, and that was the thing like, part of it too, was that with vape carts and when I couldn't get any effects off vape cards till I went nasally because of the terpenes. And part of, it was learning about two, three things. The only cart I will use is anything that's fresh rosin on the hash person. I grew up in Northern Ontario, so we had, you know. Biker hash and, um, whatever someone grew under the hydro lines. Right. And, uh, now we've got a whole bunch that we're going to make into hash. We're just, the weather's a little too cold to do the ice hash right now. But, uh. Yeah. Um, you, you know, you probably have patients has seen that and, and we can go on a whole thing about bad research in cannabis and people who consume nicotine, the smokers and tokers, right? Yeah. Yeah. And they still like to talk, but they cough. Yeah, the COPD years. We have a colleague who's like that and she's in her sixties and you know, she doesn't smoke cigarettes anymore. But I asked her about her smoking history because you know I was in smoking cessation and you I said, so how, how much was your smoking? She goes, I could eat them. She said that's how much I'll have so she's the she's a cannabis consumer loves to inhale but coughs a lung out every time right but she'll even on a vape cart but as soon as she goes through her nose guess what she doesn't cough so there's a there's probably a list of things about we can go through about what you know what happens when you know good things about inhaling nasally and one is it reduces cough because that's what your nose is made to do. It slows down the airflow and it puts it puts humidity if it needs it or changes the temperature of the vapor to mimic your body temperature. And then it goes over your vocal cords and everything else. So you don't cough. It really can make a difference. But at the same time, some people, you know, uh, on your diabetes one, yes, always low and slow, even with nasal inhalation. We always used to do this. So I was like that too, till I had my physics training in an aerosol therapy and fine particle physics and, you know, anything under five microns is going to go in your lungs. Let's just put it that way. But in airflow and fluidics of dynamics. Uh, those things will go to the area of least resistance. They'll find their way.

Kirk:  I was just thinking, like I said, we are talking to Dr. Robinson about inhalation therapy for diabetics and I can't help but think that this is the way to go on not just not just vapers. You get less hydrocarbons from the actual plant-based biomass. If I was going to recommend somebody inhaled cannabis for medical purposes, the nose or through a vape, it's brilliant. It's truly a brilliant medical administration of cannabis.

Yvette Webb: You know what if you put a timer on there now you've got dose so if you time your inspiration

Kirk:  Is there any question I didn't ask you that I should have or that you any points you want to get across?

Yvette Webb: With regards to the noser, I think, like you said, medical and recreational. We know that we have people who are like quadriplegics, so inhaling through your nose, you don't have as much effort.

Kirk: I never thought of that either.

Yvette Webb: Because you have to cause negative pressure. In order for the air to move in your lungs. And you have a bigger volume in your cheeks to make that negative pressure than your nose. So the airflow gets up fast, high, and quickly without effort. So there's so many things about why we, you know. And if you go back to some of the history of cannabis use and what they found in archeology where they believed people were like under a blanket with the seeds or the plant material. So, you know, they weren't going with their mouth open. I think revisiting that for many reasons and looking at where those receptors are and we've had people use this for migraines, really bad TMJ and because the trigeminal nerves go in here like there's just so many different things and you know and people say oh yeah I'm interested in cannabis, but I don't want to smoke because I think they. They see the rolled cigarette. So something like this offers them something. You know, the problem in medical cannabis is we don't have any, we need something that's predictable for onset duration and effect.

Kirk:  Okay. So where can people find this product.

Yvette Webb: Um @instagram at nozzrnation and also on our new launched um Cream of the Crop Therapeutics website there's a link there for purchase and provinces that are looking at bringing it in as an accessory canvas accessory as a right now.

Kirk: Paraphernalia.

Yvette Webb: Yeah i know and that's how you code it, it ends up under smoking accessory. So we don't need to educate it.

Kirk:  Since we're carrying on this conversation, well, trouble is in Manitoba, a pharmacist, Trevor is working in a fuzzy area of his practice, because Manitoba pharmacists do not encourage their members to deal with cannabis, so Trevor is very reluctant to do much with cannabis in his practice. But I've been making this, we're allowed, the cannabis laws, the Cannabis Act allows us to make cannabis in our homes. So, I've just used extra virgin olive oil as my carrier, and then the beeswax is what gives me the consistency of melting it on. So the base oils you're talking about, are they olive oils or are they petroleum oils?

Yvette Webb: No, no this is this is a cut this is all pharma blended

Kirk:  OK.

Yvette Webb: Um, but, but there's no, um, there's no nasty stuff in it. And I don't know enough about the compounding world, um. On, on doing that, but these are creams they use for hormone replacement therapy and, and testosterone. And, but the key one was wanting to look at something. The fact that they had their own in-house data on CBD and skin penetration was, you know, was really not that they share it. Um, I've tried some other base creams. There's a company actually in Vancouver and, um, it's good, but the, the best one, and it was funny. Or one of our friends said, you know, you have an amazing pain cream. It's unfortunate. Like the industry isn't supporting it. And, and even to get it into some of the medical, um outlets, right. It was like, uh, there's so many products out there that how do you. Try and separate yourself until people try it. Yeah. Right. And the things with topicals is there's so much problems with having the, what do you call it? When, in, when you do research and you've got the.

Kirk: Control study

Yvette Webb: Yeah, the pro prophylaxis of, you know, and so for a real topical to work, you need to look at it outside of six weeks.

Kirk:  Yeah, no, that's the other thing is using it and giving your body time to absorb it and all that.

Yvette Webb: And using enough. Yeah. Yeah, you know, like you say, you, you slathered on, which is hard. Sometimes some of these products are expensive. Um, and the other thing with our products and this is to do with terpenes and smell is so important in resetting your pain and memory. And so the smell is important and and we've had different people smell our cream and they go somewhere and we had two people go to Noxzema, they smelt Nuxima. And why was that? Because when they were kids, yeah, their parents, we used to bathe them in it. Yeah. And that's where they went. Other people pick up another smell in our terpene blend. 

Kirk:  very cool, well, I got to spend some time on Cream of the Crop webpage. I didn't go there at all. I went to the Nozzr^TM, I kind of read a little bit, and then I went and read some papers.

Yvette Webb: We've got the old website up for Cream of the Crop that goes on more cannabis stuff, but we're really pulling back. And you know what, we've got all the formulations we have like real world user experience. And so we, you know, we're open to people if they want to explore that in the cannabis world, or outside of Canada into Europe, because Europe, same with Nozzr^TM or Europe. Medically promotes vaping flower as a for breakthrough pain and stuff in their medical patients.

Kirk:  We're going we're going down another rabbit hole. I know, I know.

Yvette Webb: I know. I know I know another

Kirk:  This has been this has been really cool. Yeah, this has been cool. Thanks again. And take care guys. Peace and love and

Kirk: Yeah, you too. Okay.

Kirk:  We're back, Trevor. So, um, yeah, I tickled my nose with the, with the Nozzr^TM

Trevor: Yeah and before I ask you about that, I couldn't help but try to think top of my head, I'm sure I'm missing stuff, stuff we put up people's nose in sort of pharmacy world. There's not a lot but there's definitely some. There is, so if you've got allergic rhinitis, if you got allergies, we'll quite often spray a up there, and that's... Um a topical or a local effect like we just want to sort of stay in your nose and sinuses not go to the rest of your body. If we're trying to go to, the rest, of your, body well some famous ones are Narcan like if you have an opioid overdose they're going to die you've got two ways of getting into the person you can inject it or you can spray it up their nose and up the nose works quite well. Um If you have, and it's usually children, if you have children with seizure disorders, again, when people are seizing, you don't necessarily want to put something in their mouth so they will spray Midazolam up their nose to help with the seizure. So again, we're spraying something up their nose that we want to affect their whole body. You know, if it's a seizure, literally want to go in through the nose, through the bloodstream and eventually to their brain. And it goes there fast enough to help with seizures. And then you know probably the most famous one that everybody's heard of if they haven't seen it's been in movies forever is cocaine where we're going to snort something up our nose that we want to affect our whole body so you know i just had to do a quick little rundown of things things things we put up our nose in pharmacy world

Kirk:  Yeah, I also sort of kind of did that. And I was thinking at the time I had an inner ear infection and the doctor gave me a cortical steroid to it. Yeah. And that was new to me. And again, it goes through the Eustachian tube, I guess.

Trevor: Well, yeah, we still consider that kind of a local effect. Sorry if I'm splitting hairs, but we don't care if that affects your big toe, but you know, we consider the nose and the ears and even kind of the back of the throat and the sinuses, you know all connected. So yeah, if we reduce swelling here, it unplug, for those that are just listening, I'm pointing at my ear, I'm putting up my nose and my ears. We spray stuff up the nose, but all of those, the nose ears, sinuses are all connected, so it reduces the swelling in the ears.

Kirk:  And sorry for not doing my homework, but first pass the liver and all that sort of stuff. When you're going through the nose, my understanding is that you are pretty much going straight to the brain.

Trevor: Yeah. Well, that was interesting. So let's put a pin in that. You're definitely missing the liver. So you know, you're going into the bloodstream without you know if you swallow something goes through your stomach goes the liver before goes the rest of your body. There there's lots of surface area in the nose and sinuses to absorb stuff, and lots of blood flow to absorb stuff. So you are... Definitely avoiding the liver and going straight into the bloodstream. That is for sure. Now she was mentioning and it's fascinating and I'm not saying it's untrue. I just hadn't thought about it. Your eyeballs and your sort of the chemoreceptors in your brain in your nose are kind of bits of your brain, they're sticking outside of your body. Like your eyeballs are kind of an extension of your brain that sticks outside of your body and the little chemoreceptors in your nose are kind of extensions of your brain sticking outside your body, so are we getting, if we're spraying cannabis onto the chemoreceptors in our nose, is that getting straight into the brain? Yeah, maybe, that was really, really interesting. And then, you know, that leading into, Is this a good migraine treatment stuff? I honestly not sure, but everything she said made sense.

Kirk:  Yes, yes, and I guess like when you, we're talking about a product that is for cannabis, so when you inhale cannabis through a vape or a reefer, it's going through your throat, your nasal and going down to your lungs, here it is, but it's not the same effect because I tell you. I used this, and I used it with a flower vape, and, I tell you, as I said to her, the terpenes popped. It was like, honest to God, I have never, I've never smelt, smelt is the word, you know? I have not smelt my cannabis so vividly. It did hit fast, it hit faster, and it was really enjoyable, but anyways, what I thought this was cool about is she sent this to me and she also sent me a little battery, again unsolicited on my part. She sent it to me, and the battery, I went searching for the battery. The battery was for an isolate. Isolate cannabinoid delivery system for a vape. I use flower vape and I got to tell you I wish I had this product when we were talking to Dr. Robinson when we're talking about diabetes. Episode 165 inhalation cannabis therapy benefits diabetic patients and you know Dr. Robinson basically said that it's odd for a doctor to inform their patient that they should smoke something as medicine because of course intuitively we don't want the hydrocarbons into our lungs. So a vaporizer is a much better product to use than smoking a reefer because you're getting vaporized cannabinoids and terpenes opposed to the carbon from the plant material. So, with this... I'm thinking, medicinally, this has merit. So as a medicinal cannabis user who's using vaporized flower, this Nozzr^TM might actually help. What I really liked about her story was how the whole coronavirus stuff, about how this came from nasal lavage.

Trevor: Putting terpenes up people's noses to hope, to prevent what we're gonna say, the coronavirus from getting a foothold. Yeah, I thought that was very interesting.

Kirk:  But I mean, a nasal lavage is to flush out the impurities. And some people use it. And I must tell you that in my past, I have done nasal lavages when I've been congested. And it does work. Don't use tap water. There's now some issues about tap water being bad and giving you, from our last episode about molds and funguses.

Trevor:  getting a little brain fungus.

Kirk: You'll want to use. Yes, you want to use distilled water, you know, clean water. But how she developed this through her RT practice. I am sold on it in the sense of a way of vaping cannabis. It really pops the terpenes of the flowers and its immediate response. Again, the only difficulty for me was that I found I was sneezing later in the day with irritation in the nose. But yeah, it's a fabulous product. I don't want to be seen flogging a product. That's not what my goal here is.

Trevor: You're stating your personal opinion after trying it, which I think is perfectly valid.

Kirk:  Yeah yeah so if you are using vaporized flower i would suggest checking out the Nozzr^TM as a way of appreciating your terpenes and and I gotta do more research man on on the root of administration maybe the next episode we'll come back

Trevor: Yeah no no and like I said everything she said made sense because there are sort of dangly bits of the brain into the back of the nose so is the terpene going so for sure uncontroversially it will go into the bloodstream really fast so that yeah that makes sense you know back to we'll use cocaine because everyone loves that that's why snorting cocaine works so well it goes into into the Bloodstream really quickly uh does it go directly into the brain Everything she said made sense, but yeah, you'd have to look into that a little more.

Kirk:  The interesting thing about cocaine though is that it's a vasoconstrictor, so we used to use it for extreme nosebleeds at one time.

Trevor: Yes, yeah I was going to say people love the fact that I say you know back in the day they would actually pack cocaine into people's noses and you know

Kirk:  I have back in the 80s back in these we used to have cocaine in the narcotic cupboard and it was pure uncut cocaine and We'd have to count it at every shift and there's a few times where I used it in nosebleeds stuffed it up a guy's nose. Yep

Trevor: Yeah and it worked well in dentistry too because it was a local anesthetic so it numbed the area and it stopped the bleeding you know it was good stuff you know has some other issues but you know but pharmacologically it served a purpose but we're getting away from you're getting away from Nozzr^TM. I think we should probably wrap this one up again Yvette it was fantastic talking to you for these two episodes i really enjoyed it yeah keep keep us up to date with with all the stuff that your various companies are doing.

Kirk:  It was a fun episode, and it's an interesting product. So thanks again for getting a hold of us, and cheers. Oh, who are we? I guess we need to do this ourselves.

Trevor: Yeah, we could do that again, okay. I'm Trevor Shewfelt, I'm the pharmacist.

Kirk:  I'm Kirk Nyquist, I'm the registered nurse and you are listening to Reefer Medness, the Podcast. I'm a proponent of going to our webpage. If you are a new listener, go to our web page. You can search out our topics, our guests, the affiliations, you know, the organizations we talk to. It's a researchable website. But we are found on all of the podcast podcasts, providers, platforms as Reefer Medness or Reefer Med. You know I should actually tell you the last few days I've been volunteering for the food program and the chef of the food program for that for the schools we got talking.

Trevor: Food for Thought, the program's called Food for thought. Good job.

Kirk:  And we were talking, I was talking to the chef and he found out we had a podcast as a cannabis-centric kind of guy and he's actually starting at episode one and he has moved forward and he really enjoyed Aaron Bedden in episode three and I said, buddy, you've got a couple of years of listening going on there but we have a new listener.

Trevor: Welcome aboard, and if you're a brand new listener to us too, welcome aboard, let us know what you think, and we'll talk to everybody again later.